Article
LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells.
Molecular cancer - 27 Oct 2009
Liu HaiDan, Zheng Hui, Duan Zhi, Hu DuoSha, Li Ming, Liu SuFang, Li ZiJian, Deng XiYun, Wang ZhenLian, Tang Min, Shi Ying, Yi Wei, Cao Ya
Abstract excerpt
BACKGROUND: Expression of kappa gene is under the control of distinct cis-regulatory elements, including the kappa intron enhancer (iE kappa) and the kappa 3' enhancer (3'E kappa). The active enhancers and expression of immunoglobulin is generally considered to be restricted to B lymphocytes. However, accumulating evidence indicated that epithelial cancer cells, including nasopharyngeal carcinoma (NPC) cell...
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