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Article

Cellular Target Genes of Epstein-Barr Virus Nuclear Antigen 2

14 Sept 2006

Abstract excerpt

Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) is a key determinant in the EBV-driven B-cell growth transformation process. By activating an array of viral and cellular target genes, EBNA-2 initiates a cascade of events which ultimately cause cell cycle entry and the proliferation of the infected B cell. In order to identify cellular target genes that respond to EBNA-2 in the absence of other viral factors,...

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PMID: 16973580
DOI: 10.1128/jvi.00665-06

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