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Delineation of the cis-acting element mediating EBNA-2 transactivation of latent infection membrane protein expression

1 Dec 1991

Abstract excerpt

To delineate the cis-acting element through which EBNA-2 transactivates latent membrane protein 1 (LMP1), we assayed the effect of EBNA-2 on the activity of LMP1 promoter upstream deletion mutants in the context of the LMP1 or heterologous promoters controlling chloramphenicol acetyltransferase (CAT) reporter gene expression in Epstein-Barr virus-negative Burkitt lymphoma cells. Assays of progressive 5' deletions...

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PMID: 1658373
DOI: 10.1128/jvi.65.12.6765-6771.1991

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