Article
Genetic instability at the agouti locus of the mouse (Mus musculus). I. Increased reverse mutation frequency to the Aw allele in A/a heterozygotes.
Genetics - 1 Aug 1994
Sandulache R, Neuhäuser-Klaus A, Favor J
Abstract excerpt
We have compiled the reverse mutation rate data to the white bellied agouti (Aw) allele in heterozygous A/a mice and shown it to be increased by a factor of at least 350 in comparison to the reverse mutation rate in homozygous a/a mice. Employing tightly linked flanking restriction fragment lengt...
Topics
- Agouti Signaling Protein
- Alleles
- Animals
- Crossing Over, Genetic
- DNA Mutational Analysis
- Ethylnitrosourea
- Female
- Heterozygote
- Intercellular Signaling Peptides and Proteins
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Mutant Strains
- Models, Genetic
- Mutagenesis
- Polymorphism, Restriction Fragment Length