Article
Genetic instability at the agouti locus of the mouse (Mus musculus). I. Increased reverse mutation frequency to the Aw allele in A/a heterozygotes.
Genetics - 1 Aug 1994
Sandulache R, Neuhäuser-Klaus A, Favor J
Abstract excerpt
We have compiled the reverse mutation rate data to the white bellied agouti (Aw) allele in heterozygous A/a mice and shown it to be increased by a factor of at least 350 in comparison to the reverse mutation rate in homozygous a/a mice. Employing tightly linked flanking restriction fragment length polymorphism DNA markers, we have shown that reversion to Aw is associated with crossing over in the vicinity of the...
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