Article
Analysis of polymorphic variation in drug metabolism: III. Glucuronidation and sulfation of diflunisal in man.
Clinical and investigative medicine. Medecine clinique et experimentale - 1 Aug 1994
Herman R J, Loewen G R, Antosh D M, Taillon M R, Hussein S, Verbeeck R K
Abstract excerpt
The urinary excretion of diflunisal (D) and its metabolites diflunisal sulfate (DS), diflunisal phenolic glucuronide (DPG), and diflunisal acyl glucuronide (DAG) were measured in 110 healthy, drug-free Caucasian volunteers given 50 mg of diflunisal by mouth. When expressed as fractional recoveries, DS, DPG, and DAG were strongly negatively correlated with one another. Metabolic ratios, on the other hand,...
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