Article
The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes.
Pharmacogenetics - 1 Aug 1994
Bock K W, Schrenk D, Forster A, Griese E U, Mörike K, Brockmeier D, Eichelbaum M
Abstract excerpt
The impact of gender, use of oral contraceptive steroids (OCS), coffee consumption and of smoking on the metabolism of sparteine, caffeine, and paracetamol was studied in 194 randomly selected subjects (98 male and 95 female). Thirty-eight of the male volunteers were cigarette smokers, 40 of the...
Topics
- Acetaminophen
- Adolescent
- Adult
- Caffeine
- Coffee
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Female
- Genotype
- Glucuronates
- Glucuronosyltransferase
- Humans
- Male
- Middle Aged
- Mixed Function Oxygenases
- Oxidation-Reduction
- Oxidoreductases