Article
A mechanism of drug resistance to tamoxifen in breast cancer.
The Journal of steroid biochemistry and molecular biology - 1 Dec 2002
Schafer Jennifer MacGregor, Bentrem David J, Takei Hiroyuki, Gajdos Csaba, Badve Sunil, Jordan V Craig
Abstract excerpt
Drug resistance to tamoxifen (Tam) is a significant clinical problem but the mechanism through which this occurs remains elusive. We have developed a number of xenograft models of Tam-stimulated growth that model breast cancer progression using estrogen receptor positive MCF-7 or T47D breast cancer cells. When estrogen-stimulated T47D:E2 tumors are treated long term with Tam, Tam-stimulated tumors develop...
Topics
- Animals
- Antineoplastic Agents, Hormonal
- Apoptosis
- Blotting, Western
- Breast Neoplasms
- Disease Progression
- Drug Resistance, Neoplasm
- Female
- Humans
- Immunohistochemistry
- In Situ Nick-End Labeling
- Mice
- Mice, Inbred BALB C