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Article

Antitumor action of physiological estradiol on tamoxifen-stimulated breast tumors grown in athymic mice.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2000

Yao K, Lee E S, Bentrem D J, England G, Schafer J I, O'Regan R M, Jordan V C

Abstract excerpt

The estrogen receptor (ER)-positive MCF-7 breast cancer cell line can be transplanted into athymic mice and grown into tumors with estradiol (E2) support. Tamoxifen (TAM) blocks E2-stimulated tumor growth; however, continuous TAM treatment results in transplantable tumors within a year that will grow with either E2 or TAM (M. M. Gottardis and V. C. Jordan, Cancer Res., 48: 5183-5187, 1988). Although this model...

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PMID: 10815929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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