Article
Characterization of tamoxifen stimulated MCF-7 tumor variants grown in athymic mice.
Breast cancer research and treatment - 1 Jan 1994
Wolf D M, Jordan V C
Abstract excerpt
The non-steroidal antiestrogen tamoxifen (TAM) is successfully used to treat all stages of breast cancer in both pre- and postmenopausal women. Unfortunately, most women treated with TAM eventually develop resistant tumor recurrences which require intervention with a second-line endocrine therapy, or cytotoxic chemotherapy if the recurrence is completely endocrine insensitive. There is evidence that some...
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