Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estrogen receptor mutations found in breast cancer metastases integrated with the molecular pharmacology of selective ER modulators.

Journal of the National Cancer Institute - 1 Jun 2015

Jordan V Craig, Curpan Ramona, Maximov Philipp Y

Abstract excerpt

The consistent reports of mutations at Asp538 and Tyr537 in helix 12 of the ligand-binding domain (LBD) of estrogen receptors (ERs) from antihormone-resistant breast cancer metastases constitute an important advance. The mutant amino acids interact with an anchor amino acid, Asp351, to close the LBD, thereby creating a ligand-free constitutively activated ER. Amino acids Asp 538, Tyr 537, and Asp 351 are known to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen and related hormone effects

Share to Heterografts

Share to Mutation

Share to Receptors, Estrogen

Share to Selective Estrogen Receptor Modulators

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 25838462
DOI: 10.1093/jnci/djv075
PMCID: PMC6390275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogen receptor mutations found in breast cancer metastases integrated with the molecular pharmacology of selective ER modulators.PMID 25838462Read ↗

Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes.Semantic proximity Read ↗

A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses.Semantic proximity Read ↗

Current Therapeutic Opportunities for Estrogen Receptor Mutant Breast CancerSemantic proximity Read ↗

Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer.Semantic proximity Read ↗

Estrogen receptor mutations in breast cancer--new focus on an old target.Semantic proximity Read ↗

An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer.Semantic proximity Read ↗

Understanding the mechanisms of action of estrogen receptor mutations in metastatic breast cancerSemantic proximity Read ↗

Implications of ESR1 Mutations in Hormone Receptor-Positive Breast Cancer.Semantic proximity Read ↗

Estrogen receptor mutations in breast cancer.Semantic proximity Read ↗

The Evolving Role of the Estrogen Receptor Mutations in Endocrine Therapy-Resistant Breast Cancer.Semantic proximity Read ↗

Estrogen receptor mutations and functional consequences for breast cancer.Semantic proximity Read ↗

Estrogen receptor mutations in human disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.