Article
A deletion in the second exon of an HLA-DRB1 allele found in a DR2-negative narcolepsy patient.
Human immunology - 1 May 1993
Roushdy J, Santoso S, Kalb R, Meier-Ewert K, Albert E D, Mueller-Eckhardt G
Abstract excerpt
In this report, we describe a new allele of the HLA-DRB 1 gene carrying a form of mutation that has not been observed before. It appeared in an HLA-DR2-negative narcolepsy patient who, besides HLA-DR4, revealed a serologic HLA-DR blank segregating with HLA-DQ1. Oligotyping showed that the new all...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Exons
- Female
- Gene Deletion
- Genes, MHC Class II
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Narcolepsy
- Pedigree
- Polymerase Chain Reaction
- RNA, Messenger