N-acetylation and debrisoquine hydroxylation polymorphisms in patients with Gilbert's syndrome.

doi:10.1111/j.1365-2125.1991.tb03932.x

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Article

N-acetylation and debrisoquine hydroxylation polymorphisms in patients with Gilbert's syndrome.

British journal of clinical pharmacology - 1 Oct 1991

Siegmund W, Fengler J D, Franke G, Zschiesche M, Eike O, Eike E, Meisel P, Wulkow R

Abstract excerpt

1. N-acetylation and debrisoquine hydroxylation phenotypes were determined in 54 patients with Gilbert's syndrome and in 247 (sulphamethazine) and 76 (debrisoquine) non-related healthy volunteers. 2. Forty (74.1%) of the patients and 135 (54.7%) of the healthy volunteers were slow acetylators (ch...

Topics

Acetylation
Adolescent
Adult
Aged
Debrisoquin
Female
Gilbert Disease
Humans
Hydroxylation
Male
Middle Aged
Phenotype
Polymorphism, Genetic

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