Article
Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity.
Journal of virology - 1 Feb 1990
Radziwill G, Tucker W, Schaller H
Abstract excerpt
To correlate the hepatitis B virus P gene with the enzymatic activities predicted to participate in hepadnavirus reverse transcription, a series of P gene mutants containing missense mutations, in-phase insertions, and in-phase deletions was constructed by site-directed mutagenesis. These mutants...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Chromosome Deletion
- Endoribonucleases
- Genes, Viral
- Genetic Complementation Test
- Hepatitis B virus
- Humans
- Introns
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Plasmids
- Ribonuclease H
- Viral Structural Proteins