Article
Isolation of an allele of reeler by insertional mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America - 8 Nov 1994
Miao G G, Smeyne R J, D'Arcangelo G, Copeland N G, Jenkins N A, Morgan J I, Curran T
Abstract excerpt
Reeler (rl) is an autosomal recessive mutation that affects migration of postmitotic neurons in the mouse central nervous system. The reeler (rl/rl) mouse displays a disruption of laminar structures in both the cerebellum and the forebrain and it exhibits tremors, dystonia, and ataxia. The molecu...
Topics
- Alleles
- Animals
- Brain
- Chromosome Mapping
- Gene Expression Regulation, Developmental
- Genes
- Mice
- Mice, Neurologic Mutants
- Mice, Transgenic
- Mutagenesis, Insertional
- RNA, Messenger
- Restriction Mapping