Article
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler.
Nature - 20 Apr 1995
D'Arcangelo G, Miao G G, Chen S C, Soares H D, Morgan J I, Curran T
Abstract excerpt
The autosomal recessive mouse mutation reeler leads to impaired motor coordination, tremors and ataxia. Neurons in affected mice fail to reach their correct locations in the developing brain, disrupting the organization of the cerebellar and cerebral cortices and other laminated regions. Here we...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Brain
- Cell Adhesion Molecules, Neuronal
- Cell Movement
- Cloning, Molecular
- Embryonic and Fetal Development
- Extracellular Matrix Proteins
- Gene Deletion
- Mice
- Mice, Neurologic Mutants
- Molecular Sequence Data
- Nerve Tissue Proteins
- Neurons
- Phenotype
- RNA, Messenger