Article
A reeler mutant mouse with a new, spontaneous mutation in the reelin gene.
Brain research. Molecular brain research - 30 Sept 2002
Andersen Tom E, Finsen Bente, Goffinet Andre M, Issinger Olaf-Georg, Boldyreff Brigitte
Abstract excerpt
In one of our mouse colonies a reeler-like phenotype appeared spontaneously. The brain histology was identical to the known reeler phenotype. Northern and Western blot analysis and a complementation test showed that the defect is located to the reelin gene. Southern blot and PCR analysis together with information obtained from sequence databases revealed that this defective reelin gene had an approximately 24-kb...
Topics
- Animals
- Base Sequence
- Cell Adhesion Molecules, Neuronal
- Cerebellum
- DNA
- Down-Regulation
- Exons
- Extracellular Matrix Proteins
- Female
- Gene Deletion
- Male
- Mice
- Mice, Neurologic Mutants
- Mutation
- Nerve Tissue Proteins
- Phenotype
- RNA, Messenger
- Reelin Protein