High-speed positional cloning based on restriction landmark genome scanning.

doi:10.1006/meth.1997.0544

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Article

High-speed positional cloning based on restriction landmark genome scanning.

Methods (San Diego, Calif.) - 1 Dec 1997

Okazaki Y, Hayashizaki Y

Abstract excerpt

Restriction landmark genome scanning (RLGS) was developed as a method of genome analysis that is based on the concept that restriction enzyme sites can be used as landmarks. In this article, we demonstrate how this method can be used for the systematic, successful positional cloning of mouse muta...

Topics

Animals
Cloning, Molecular
DNA
Genetic Markers
Genome
Mice
Mutation
Restriction Mapping

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