Article
High-speed positional cloning based on restriction landmark genome scanning.
Methods (San Diego, Calif.) - 1 Dec 1997
Okazaki Y, Hayashizaki Y
Abstract excerpt
Restriction landmark genome scanning (RLGS) was developed as a method of genome analysis that is based on the concept that restriction enzyme sites can be used as landmarks. In this article, we demonstrate how this method can be used for the systematic, successful positional cloning of mouse mutant reeler gene. The major advantage of the RLGS method is that it allows the scanning of several thousand spots/loci...
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