Article
Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 1997
Goldowitz D, Cushing R C, Laywell E, D'Arcangelo G, Sheldon M, Sweet H O, Davisson M, Steindler D, Curran T
Abstract excerpt
Analysis of the molecular basis of neuronal migration in the mammalian CNS relies critically on the discovery and identification of genetic mutations that affect this process. Here, we report the detailed cerebellar phenotype caused by a new autosomal recessive neurological mouse mutation, scramb...
Topics
- Animals
- Ataxia
- Cell Adhesion Molecules, Neuronal
- Cell Movement
- Cerebellum
- Extracellular Matrix
- Extracellular Matrix Proteins
- Gene Expression Regulation, Developmental
- Mice
- Mice, Inbred C3H
- Mice, Neurologic Mutants
- Nerve Tissue Proteins
- Neuroglia