Article
Cell of origin in radiation-induced premalignant thymocytes with differentiation capability in mice conditionally losing one Bcl11b allele.
Cancer science - 1 Aug 2013
Go Rieka, Hirose Satoshi, Katsuragi Yoshinori, Obata Miki, Abe Manabu, Mishima Yukio, Sakimura Kenji, Kominami Ryo
Abstract excerpt
Bcl11b is a haploinsufficient tumor suppressor, mutations or deletion of which has been found in 10-16% of T-cell acute lymphoblastic leukemias. Bcl11b(KO) (/+) heterozygous mice are susceptible to thymic lymphomas, a model of T-cell acute lymphoblastic leukemia, when γ-irradiated, and irradiated Bcl11b(KO) (/+) mice generate clonally expanding or premalignant thymocytes before thymic lymphoma development. Cells...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.