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Article

Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress

12 Jan 2016

Abstract excerpt

Anaplastic large cell lymphoma (ALCL) is a peripheral T-cell lymphoma presenting mostly in children and young adults. The natural progression of this disease is largely unknown as is the identity of its true cell of origin. Here we present a model of peripheral ALCL pathogenesis where the malignancy is initiated in early thymocytes, before T-cell receptor (TCR) β-rearrangement, which is bypassed in CD4/NPM-ALK...

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PMID: 26753883
DOI: 10.1038/ncomms10087

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