Utilization of selenocysteyl-tRNA[Ser]Sec and seryl-tRNA[Ser]Sec in protein synthesis.

Article

Utilization of selenocysteyl-tRNA[Ser]Sec and seryl-tRNA[Ser]Sec in protein synthesis.

The Journal of biological chemistry - 25 Nov 1994

Jung J E, Karoor V, Sandbaken M G, Lee B J, Ohama T, Gesteland R F, Atkins J F, Mullenbach G T, Hill K E, Wahba A J

Abstract excerpt

The UGA selenocysteine (Sec) codon in glutathione peroxidase mRNA and in selenoprotein P and the UGA stop codon in rabbit beta-globin mRNA were employed to study the utilization of Sec-tRNA[Ser]Sec and Ser-tRNA[Ser]Sec in protein synthesis. In vitro Ser-tRNA[Ser]Sec served as a suppressor of the...

Topics

Acylation
Animals
Codon
Glutathione Peroxidase
Mutation
Protein Biosynthesis
RNA, Transfer, Amino Acyl
Rabbits
Ribosomes

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