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Article

Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA.

Biochemical and biophysical research communications - 17 Jun 2011

Kim Jin Young, Carlson Bradley A, Xu Xue-Ming, Zeng Yu, Chen Shawn, Gladyshev Vadim N, Lee Byeong Jae, Hatfield Dolph L

Abstract excerpt

There are two isoforms of selenocysteine (Sec) tRNA([Ser]Sec) that differ by a single methyl group, Um34. The non-Um34 isoform supports the synthesis of a subclass of selenoproteins, designated housekeeping, while the Um34 isoform supports the expression of another subclass, designated stress-related selenoproteins. Herein, we investigated the relationship between tRNA([Ser]Sec) aminoacylation and Um34 synthesis...

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Identifiers

PMID: 21624347
DOI: 10.1016/j.bbrc.2011.05.096
PMCID: PMC3124823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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