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Article

Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma.

International journal of cancer - 15 Dec 2007

Patel Heena, Polanco-Echeverry Guadalupe, Segditsas Stefania, Volikos Emmanouil, McCart Amy, Lai Cecilia, Guenther Thomas, Zaitoun Abed, Sieber Oliver, Ilyas Mohammed, Northover John, Silver Andrew

Abstract excerpt

Human papilloma virus (HPV) infection is considered as an important aetiological factor for anal squamous cell carcinoma (ASCC) but is not sufficient for tumour progression. This carcinoma is poorly understood at the molecular level. Using the largest cohort of cases to date we investigated the molecular mechanisms underlying ASCC development, in particular the roles of TP53, MDM2 and AKT. Viral infection in our...

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Identifiers

PMID: 17721920
DOI: 10.1002/ijc.23028

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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