Expression of p53, p16 ^INK4A , pRb, p21 ^WAF1/CIP1 , p27 ^KIP1 , cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma

Abstract excerpt

CONCLUSIONS: Human papilloma virus (HPV) was associated with sinonasal inverted papilloma (SIP) in 14/20 (70%) patients with a prevalence of HPV 6/11; alterations of the cell cycle proteins were statistically significant. OBJECTIVES: We investigated SIPs relationships between HPV infection and aberrant expression of cell cycle proteins. MATERIALS AND METHODS: Twenty SIPs were evaluated for p53, p16(INK4a), pRb,...

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