The structural basis of molecular genetic deletions. An integration of classical cytogenetic and molecular analyses in pancreatic adenocarcinoma.

Article

The structural basis of molecular genetic deletions. An integration of classical cytogenetic and molecular analyses in pancreatic adenocarcinoma.

The American journal of pathology - 1 Feb 1997

Brat D J, Hahn S A, Griffin C A, Yeo C J, Kern S E, Hruban R H

Abstract excerpt

Molecular genetic alterations are known to be important in human carcinoma, but the structural basis of these changes is largely unknown. To examine the basis of these changes, we compared the karyotypic chromosomal abnormalities of primary pancreatic adenocarcinomas with the molecular changes id...

Topics

Adenocarcinoma
Aged
Aged, 80 and over
Alleles
Cytogenetics
Gene Deletion
Heterozygote
Homozygote
Humans
Karyotyping
Middle Aged
Molecular Biology
Pancreatic Neoplasms

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.