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Article

The AAA+ ClpX machine unfolds a keystone subunit to remodel the Mu transpososome.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2010

Abdelhakim Aliaa H, Sauer Robert T, Baker Tania A

Abstract excerpt

A hyperstable complex of the tetrameric MuA transposase with recombined DNA must be remodeled to allow subsequent DNA replication. ClpX, a AAA+ enzyme, fulfills this function by unfolding one transpososome subunit. Which MuA subunit is extracted, and how complex destabilization relates to establishment of the correct directionality (left to right) of Mu replication, is not known. Here, using altered-specificity...

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Source

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Identifiers

PMID: 20133746
DOI: 10.1073/pnas.0910905106
PMCID: PMC2823858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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