Article
Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase.
Genes & development - 15 Oct 1994
Ogura K, Wicky C, Magnenat L, Tobler H, Mori I, Müller F, Ohshima Y
Abstract excerpt
Mutations in the unc-51 gene of the nematode Caenorhabditis elegans result in various abnormalities in axonal elongation and axonal structures. We cloned the unc-51 gene by tagging with the transposon Tc1. The wild-type unc-51 gene, which rescued the mutant phenotypes, encodes a novel serine/threonine kinase of 856 amino acids. Mutation sites were identified in the unc-51 gene of six mutants. A Lys-->Met mutation...
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