Article
Caffeine metabolism in cystic fibrosis: enhanced xanthine oxidase activity.
Clinical pharmacology and therapeutics - 1 Nov 1994
Hamelin B A, Xu K, Vallé F, Manseau L, Richer M, LeBel M
Abstract excerpt
STUDY OBJECTIVE: To characterize the activities of the P450 mixed-function oxidase CYP1A2 as well as the cytosolic enzymes N-acetyltransferase and xanthine oxidase using caffeine as a probe in children with cystic fibrosis compared to age-matched healthy control subjects. METHODS: After administr...
Topics
- Alleles
- Aryl Hydrocarbon Hydroxylases
- Arylamine N-Acetyltransferase
- Base Sequence
- Caffeine
- Case-Control Studies
- Child
- Child, Preschool
- Chromatography, High Pressure Liquid
- Cystic Fibrosis
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 CYP2A6
- Cytochrome P-450 Enzyme System
- Female
- Humans
- Liver
- Male
- Mixed Function Oxygenases