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Article

Caffeine metabolism in cystic fibrosis: enhanced xanthine oxidase activity.

Clinical pharmacology and therapeutics - 1 Nov 1994

Hamelin B A, Xu K, Vallé F, Manseau L, Richer M, LeBel M

Abstract excerpt

STUDY OBJECTIVE: To characterize the activities of the P450 mixed-function oxidase CYP1A2 as well as the cytosolic enzymes N-acetyltransferase and xanthine oxidase using caffeine as a probe in children with cystic fibrosis compared to age-matched healthy control subjects. METHODS: After administration of caffeine (cola beverage) to 12 children with cystic fibrosis (age range, 5 to 11 years) and 12 healthy control...

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PMID: 7955816
DOI: 10.1038/clpt.1994.173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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