Article
Caffeine metabolism in a healthy Spanish population: N-acetylator phenotype and oxidation pathways.
Clinical pharmacology and therapeutics - 1 Mar 1994
Carrillo J A, Benítez J
Abstract excerpt
We studied the oxidative and N-acetylator caffeine metabolic profile in 107 healthy Spanish volunteers. Smokers had significantly higher N-1- and N-3-demethylations activities than nonsmokers (p = 0.03 and p = 0.02, respectively), and the three caffeine demethylations indexes were strongly correlated with each other (r > 0.7; p < 0.001). Our in vivo studies suggest that CYP1A2 is involved, at least in part, in...
Topics
- Acetylation
- Adult
- Caffeine
- Female
- Genetic Variation
- Humans
- Male
- Oxidation-Reduction
- Phenotype
- Reference Values
- Spain
- Time Factors