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Article

A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine test.

Clinical pharmacology and therapeutics - 1 Aug 2002

Saruwatari Junji, Nakagawa Kazuko, Shindo Junichi, Tajiri Takahiro, Fujieda Masaki, Yamazaki Hiroshi, Kamataki Tetsuya, Ishizaki Takashi

Abstract excerpt

OBJECTIVE: We assessed in vivo activities of cytochrome P450 1A2 (CYP1A2), N-acetyltransferase 2, and xanthine oxidase in Japanese residents of Kyushu, the southern island of Japan. METHODS: One hundred eighty-two healthy volunteers (108 men and 74 women) received a 150-mg oral dose of caffeine before they went to sleep. The concentrations of caffeine, caffeine metabolites, and uric acid in their overnight urine...

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Identifiers

PMID: 12189367
DOI: 10.1067/mcp.2002.126173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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