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Article

Caffeine phenotyping of cytochrome P4501A2, N-acetyltransferase, and xanthine oxidase in patients with familial adenomatous polyposis.

Gut - 1 Feb 1995

Spigelman A D, Farmer K C, Oliver S, Nugent K P, Bennett P N, Notarianni L J, Dobrocky P, Phillips R K

Abstract excerpt

Patients with familial adenomatous polyposis (FAP) and age and sex matched controls were tested for cytochrome P4501A2 (CYP1A2), N-acetyltransferase, and xanthine oxidase activities using caffeine urinary metabolites as a discriminator. FAP patients showed significant underactivity of N-acetyltransferase (which inactivates some carcinogens) and significant overactivity of CYP1A2 (which activates some...

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Source

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Identifiers

PMID: 7883225
DOI: 10.1136/gut.36.2.251
PMCID: PMC1382412

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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