Article
Caffeine phenotyping of cytochrome P4501A2, N-acetyltransferase, and xanthine oxidase in patients with familial adenomatous polyposis.
Gut - 1 Feb 1995
Spigelman A D, Farmer K C, Oliver S, Nugent K P, Bennett P N, Notarianni L J, Dobrocky P, Phillips R K
Abstract excerpt
Patients with familial adenomatous polyposis (FAP) and age and sex matched controls were tested for cytochrome P4501A2 (CYP1A2), N-acetyltransferase, and xanthine oxidase activities using caffeine urinary metabolites as a discriminator. FAP patients showed significant underactivity of N-acetyltra...
Topics
- Acetyltransferases
- Adenomatous Polyposis Coli
- Adolescent
- Adult
- Aged
- Caffeine
- Colectomy
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 Enzyme System
- Female
- Humans
- Male
- Middle Aged
- Oxidoreductases
- Phenotype
- Time Factors
- Xanthine Oxidase