Article
A novel pancreatic endocrine tumor suppressor gene locus on chromosome 3p with clinical prognostic implications.
The Journal of clinical investigation - 15 Jul 1997
Chung D C, Smith A P, Louis D N, Graeme-Cook F, Warshaw A L, Arnold A
Abstract excerpt
The molecular pathogenesis of pancreatic endocrine tumors is largely unknown. Such tumors are more likely to develop in individuals with the von Hippel-Lindau (VHL) syndrome. We sought to determine whether allelic loss of the recently identified VHL tumor suppressor gene on chromosome 3p25-26 occurs in the more common sporadic forms of these tumors. Allelic loss on chromosome 3p was identified in 33% of 43...
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