Article
Molecular genetic studies of sporadic and familial renal cell carcinoma.
The Urologic clinics of North America - 1 May 1993
Gnarra J R, Glenn G M, Latif F, Anglard P, Lerman M I, Zbar B, Linehan W M
Abstract excerpt
Renal cell carcinoma (RCC) occurs predominantly as a sporadic disease but has familial forms. Cytogenetic and DNA deletion analyses show that both sporadic and familial RCC tumors arise as the result of chromosomal deletions in the 3p13-p26 region. von Hippel-Lindau (VHL) disease is a hereditary, multifocal syndrome that includes, among several affected organs, multiple, bilateral renal cysts and RCC. Although...
Topics
- Carcinoma, Renal Cell
- Cell Line
- Chromosome Deletion
- Chromosomes, Human, Pair 3
- Female
- Genes, Tumor Suppressor
- Genetic Linkage
- Humans
- Kidney Neoplasms
- Male
- Mutation