Article
Involvement of 3p deletions in sporadic and hereditary forms of renal cell carcinoma.
Genes, chromosomes & cancer - 1 Sept 1991
Boldog F, Arheden K, Imreh S, Strömbeck B, Szekely L, Erlandsson R, Marcsek Z, Sumegi J, Mitelman F, Klein G
Abstract excerpt
Deletions of the short arm of chromosome 3 and associated allele losses have been reported in the majority of sporadic renal cell carcinomas (RCC). On the basis of the combined cytogenetic and molecular data, it is reasonable to assume that a putative RCC locus, which contributes to tumor development by its loss, is located telomerically of the D3F15S2 site. Using H3E4, a D3F15S2-specific probe, we have isolated...
Topics
- Alleles
- Carcinoma, Renal Cell
- Chromosome Banding
- Chromosome Deletion
- Chromosomes, Human, Pair 3
- Humans
- Karyotyping
- Kidney Neoplasms
- Lymphocytes