Article
Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma.
Human molecular genetics - 1 Dec 1994
Foster K, Prowse A, van den Berg A, Fleming S, Hulsbeek M M, Crossey P A, Richards F M, Cairns P, Affara N A, Ferguson-Smith M A
Abstract excerpt
Loss of heterozygosity (LOH) studies have suggested that somatic mutations of a tumour suppressor gene or genes on chromosome 3p are a critical event in the pathogenesis of non-familial renal cell carcinoma (RCC). Germline mutations of the von Hippel-Lindau (VHL) disease gene predispose to early onset and multifocal clear cell renal cell carcinoma, and the mechanism of tumorigenesis in VHL disease is consistent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.