Article
Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma.
Human molecular genetics - 1 Dec 1994
Foster K, Prowse A, van den Berg A, Fleming S, Hulsbeek M M, Crossey P A, Richards F M, Cairns P, Affara N A, Ferguson-Smith M A
Abstract excerpt
Loss of heterozygosity (LOH) studies have suggested that somatic mutations of a tumour suppressor gene or genes on chromosome 3p are a critical event in the pathogenesis of non-familial renal cell carcinoma (RCC). Germline mutations of the von Hippel-Lindau (VHL) disease gene predispose to early...
Topics
- Adenocarcinoma, Clear Cell
- Chromosome Mapping
- Chromosomes, Human, Pair 3
- Genes, Tumor Suppressor
- Heterozygote
- Humans
- Kidney Neoplasms
- Mutation
- von Hippel-Lindau Disease