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Article

Nonhomologous chromatid exchange in hereditary and sporadic renal cell carcinomas.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1991

Kovacs G, Kung H F

Abstract excerpt

For the development of renal cell carcinomas, it has been suggested that a germ-line or somatic mutation occurs on one of the homologous chromosomes 3p, and subsequently the other 3p segment is lost. We have examined the karyotype and/or the allelic combination on chromosomes 3 and 5 by restriction fragment length polymorphism analysis in normal kidney and tumor samples from 28 renal cell carcinomas that...

Topics

Blotting, Southern
Carcinoma, Renal Cell
Chromatids
Chromosome Banding
Crossing Over, Genetic
DNA, Neoplasm
Female
Genotype
Humans
In Vitro Techniques
Karyotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kidney Neoplasms

Nucleic Acid Hybridization

Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1986366
DOI: 10.1073/pnas.88.1.194
PMCID: PMC50776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1986366-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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