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Article

Identification of domains of netrin UNC-6 that mediate attractive and repulsive guidance and responses from cells and growth cones.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2002

Lim Yoo-shick, Wadsworth William G

Abstract excerpt

Netrin UNC-6 is a protein secreted from ventral cells that guides cell and growth cone migrations in Caenorhabditis elegans. Previously it was shown that UNC-6 domain V-2 regulates dorsal guidance activity and domain C regulates an activity that prevents the branching of axons when they respond to the N-terminal domains. Because these results indicate that the biological activities of UNC-6 are mediated through...

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PMID: 12177204
PMCID: PMC6757861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Identification of domains of netrin UNC-6 that mediate attractive and repulsive guidance and responses from cells and growth cones.PMID 12177204Read ↗

Domain-specific mutations in unc-6/Netrin differentially affect dorsal-ventral axon pathfinding in Caenorhabditis elegans.Semantic proximity Read ↗

The C domain of netrin UNC-6 silences calcium/calmodulin-dependent protein kinase- and diacylglycerol-dependent axon branching in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans.Semantic proximity Read ↗

Netrin UNC-6 and the regulation of branching and extension of motoneuron axons from the ventral nerve cord of Caenorhabditis elegans.Semantic proximity Read ↗

ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans.Semantic proximity Read ↗

Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity.Semantic proximity Read ↗

UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans.Semantic proximity Read ↗

Axon guidance mechanisms in Caenorhabditis elegans.Semantic proximity Read ↗

Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites.Semantic proximity Read ↗

MADD-4 is a secreted cue required for midline-oriented guidance in Caenorhabditis elegans.Semantic proximity Read ↗

Netrin (UNC-6) mediates dendritic self-avoidance.Semantic proximity Read ↗

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