Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras.

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Article

Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras.

Blood - 15 Nov 1994

Kalra R, Paderanga D C, Olson K, Shannon K M

Abstract excerpt

Children with neurofibromatosis, type 1 (NF-1) are at increased risk of developing malignant myeloid disorders and their bone marrows frequently show loss of the normal allele of the NF1 tumor-suppressor gene. NF1 encodes a protein called neurofibromin, which accelerates guanosine triphosphate (G...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Bone Marrow
Child
Cloning, Molecular
Codon
Exons
Genes, Neurofibromatosis 1
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Neurofibromin 1

Oligodeoxyribonucleotides

Point Mutation

Preleukemia

Protein Biosynthesis

Source

Open in PubMed

Identifiers

PMID: 7949098

Genes

KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7949098-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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