Article
Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras.
Blood - 15 Nov 1994
Kalra R, Paderanga D C, Olson K, Shannon K M
Abstract excerpt
Children with neurofibromatosis, type 1 (NF-1) are at increased risk of developing malignant myeloid disorders and their bone marrows frequently show loss of the normal allele of the NF1 tumor-suppressor gene. NF1 encodes a protein called neurofibromin, which accelerates guanosine triphosphate (GTP) hydrolysis on the p21ras (Ras) family of signaling proteins. We used a genetic approach to test the hypothesis that...
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