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Article

Monosomy 7 and activating RAS mutations accompany malignant transformation in patients with congenital neutropenia

15 Dec 1995

Abstract excerpt

Individuals with severe forms of congenital neutropenia suffer from recurrent infections. The therapeutic use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) to increase the neutrophil count is associated with fewer infections and an improved quality of life. However, the long-term effects of this new therapy are largely unknown. In particular, it is unclear if myeloid leukemia, a known...

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Identifiers

PMID: 8541548
DOI: 10.1182/blood.v86.12.4579.bloodjournal86124579

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