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Article

Nf1 and Gmcsf interact in myeloid leukemogenesis.

Molecular cell - 1 Jan 2000

Birnbaum R A, O'Marcaigh A, Wardak Z, Zhang Y Y, Dranoff G, Jacks T, Clapp D W, Shannon K M

Abstract excerpt

The NF1 tumor suppressor gene encodes neurofibromin, a GTPase-activating protein (GAP) for p21ras (Ras). Children with NF1 are predisposed to juvenile myelomonocytic leukemia (JMML). Some heterozygous Nf1 mutant mice develop a similar myeloproliferative disorder (MPD), and adoptive transfer of Nf1-deficient fetal liver cells consistently induces this MPD. Human JMML and murine Nf1-deficient cells are...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10678181
DOI: 10.1016/s1097-2765(00)80415-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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