Article
Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1.
Cancer - 1 Apr 1997
Maris J M, Wiersma S R, Mahgoub N, Thompson P, Geyer R J, Hurwitz C G, Lange B J, Shannon K M
Abstract excerpt
BACKGROUND: Children with neurofibromatosis type 1 (NF1) are at increased risk of developing benign and malignant solid tumors as well as hematologic malignancies, including de novo juvenile chronic myelogenous leukemia, monosomy 7 syndrome, and acute myelogenous leukemia. The normal NF1 allele i...
Topics
- Blotting, Southern
- Bone Marrow
- Child
- Child, Preschool
- Chromosome Deletion
- Chromosomes, Human, Pair 7
- DNA, Neoplasm
- Female
- Genes, Neurofibromatosis 1
- Genes, ras
- Humans
- Male