Article
Mutations of the ras proto-oncogenes in childhood monosomy 7.
Blood - 1 Feb 1991
Neubauer A, Shannon K, Liu E
Abstract excerpt
ras gene mutations are the most frequent molecular changes found in the preleukemic syndromes of adults and may play a role in initiating these diseases and in their progression to acute leukemia. However, little is known about the incidence or importance of these genetic mutations in childhood myeloproliferative states (MPS). The bone marrow (BM) monosomy 7 syndrome accounts for a large percentage of childhood...
Topics
- Bone Marrow
- Child
- Child, Preschool
- Chromosome Deletion
- Chromosomes, Human, Pair 7
- Female
- Gene Amplification
- Genes, ras
- Humans
- Infant
- Leukemia, Myeloid, Acute
- Male