Article
Effects of three genetic loci in a pedigree with multiple lipoprotein phenotypes.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Jan 2000
Emi M, Hegele R M, Hopkins P N, Wu L L, Plaetke R, Williams R R, Lalouel J M
Abstract excerpt
In the course of familial investigations of coronary artery disease, we identified an extended kinship in which several members were affected with type IIa hyperlipoproteinemia (HLPIIa), type III dyslipoproteinemia (DLPIII), or hypobetalipoproteinemia (HBLP). To study the genetic defects responsible for plasma lipoprotein abnormalities in this pedigree and to investigate the phenotypic effect of different...
Topics
- Adolescent
- Adult
- Apolipoprotein E2
- Apolipoprotein E3
- Apolipoproteins E
- Child
- Child, Preschool
- Cholesterol, LDL
- DNA
- Female
- Genetic Linkage