Article
Influence of apolipoprotein E genotypes on plasma lipid and lipoprotein concentrations: results from a segregation analysis in pedigrees with molecularly defined familial hypercholesterolemia.
Genetic epidemiology - 1 Jan 1996
Friedlander Y, Leitersdorf E
Abstract excerpt
Familial hypercholesterolemia (FH) is a monogenic disorder caused by mutations in the low-density lipoprotein (LDL) receptor gene. Large variations in plasma lipids and lipoprotein levels have been observed in FH families. These may be caused by other environmental and genetic factors of which ap...
Topics
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Apolipoproteins E
- Case-Control Studies
- Child
- Child, Preschool
- Environmental Health
- Evaluation Studies as Topic
- Female
- Genetic Variation
- Heterozygote
- Humans
- Hyperlipoproteinemia Type II
- Infant
- Lipids