Article
Evidence for a major gene accounting for mild elevation in LDL cholesterol: the NHLBI Family Heart Study.
Annals of human genetics - 1 Sept 1999
Coon H, Leppert M F, Kronenberg F, Province M A, Myers R H, Arnett D K, Eckfeldt J H, Heiss G, Williams R R, Hunt S C
Abstract excerpt
Studies of rare Mendelian disorders of low density lipoprotein cholesterol (LDL-C) metabolism have identified specific genetic mutations in the LDL receptor and apolipoprotein B. Although these rare mutations account for a small proportion of LDL-C variation, twin and adoption studies indicate that at least 50% of the overall LDL-C observed variation is genetically determined. In a heterogeneous sample of 3227...
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