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Article

Suppression of H-ras-mediated transformation in NIH3T3 cells by a ras ribozyme.

Biochemical pharmacology - 7 Oct 1994

Funato T, Shitara T, Tone T, Jiao L, Kashani-Sabet M, Scanlon K J

Abstract excerpt

Murine NIH3T3 cells were used to study the effect of ribozymes on H-ras-mediated transformation. Parental 3T3 cells were transfected with the activated H-ras gene. H-ras-transformed cells had altered morphology and increased colony formation in soft agar in contrast to untransfected 3T3 cells. A hammerhead ribozyme (site-specific ribonuclease) designed to cleave codon 12 (GUC) of the activated H-ras RNA was...

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Identifiers

PMID: 7945447
DOI: 10.1016/0006-2952(94)90572-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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