Suppression of H-ras-mediated transformation in NIH3T3 cells by a ras ribozyme.

doi:10.1016/0006-2952(94)90572-x

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Article

Suppression of H-ras-mediated transformation in NIH3T3 cells by a ras ribozyme.

Biochemical pharmacology - 7 Oct 1994

Funato T, Shitara T, Tone T, Jiao L, Kashani-Sabet M, Scanlon K J

Abstract excerpt

Murine NIH3T3 cells were used to study the effect of ribozymes on H-ras-mediated transformation. Parental 3T3 cells were transfected with the activated H-ras gene. H-ras-transformed cells had altered morphology and increased colony formation in soft agar in contrast to untransfected 3T3 cells. A...

Topics

3T3 Cells
Animals
Base Sequence
Cell Transformation, Neoplastic
Genes, ras
Mice
Molecular Sequence Data
Mutation
Oncogenes
Plasmids
RNA, Catalytic
Suppression, Genetic
Transfection

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