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Article

Reversal of the malignant phenotype by an anti-ras ribozyme.

Antisense research and development - 1 Jan 1992

Kashani-Sabet M, Funato T, Tone T, Jiao L, Wang W, Yoshida E, Kashfinn B I, Shitara T, Wu A M, Moreno J G

Abstract excerpt

In this study a ribozyme (catalytic RNA) was designed to site specifically cleave the mRNA of the activated H-ras gene expressed in human bladder carcinoma EJ cells. The optimal conditions for catalytic cleavage by the ribozyme were demonstrated in vitro. A synthetic DNA encoding the ribozyme was cloned into a mammalian expression vector (pH beta APr-1) and transfected into EJ cells. The expressed ribozyme...

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Identifiers

PMID: 1422085
DOI: 10.1089/ard.1992.2.3

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