Suppression of the malignant phenotype of melanoma cells by anti-oncogene ribozymes.

doi:10.1111/1523-1747.ep12340688

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Article

Suppression of the malignant phenotype of melanoma cells by anti-oncogene ribozymes.

The Journal of investigative dermatology - 1 Feb 1996

Ohta Y, Kijima H, Kashani-Sabet M, Scanlon K J

Abstract excerpt

The activation of signal transduction pathways by mutation or overexpression of cellular oncogenes has been associated with neoplastic transformation. In this study, we addressed the therapeutic potential of ribozymes targeted against the activated H-ras oncogene as well as against the nuclear pr...

Topics

Antibodies
Base Sequence
Blotting, Northern
Gene Expression
Genes, ras
Humans
Melanoma
Molecular Sequence Data
Oncogenes
Phenotype
RNA, Catalytic
Tumor Cells, Cultured

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