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Article

Ribozymes designed to inhibit transformation of NIH3T3 cells by the activated c-Ha-ras gene.

Gene - 15 Aug 1992

Koizumi M, Kamiya H, Ohtsuka E

Abstract excerpt

We have designed hammerhead ribozymes that cleave c-Ha-ras mRNA mutated at codon 12 (GGU----GUU). Plasmids containing the ribozyme-encoding genes were expressed under the control of the long terminal repeats of Rous sarcoma virus in NIH3T3 cells transfected with the activated c-Ha-ras gene. These ribozymes were found to inhibit formation of foci (by about 50%) by cleaving the oncogene mRNA, rather than by...

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Identifiers

PMID: 1639266
DOI: 10.1016/0378-1119(92)90727-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ribozymes designed to inhibit transformation of NIH3T3 cells by the activated c-Ha-ras gene.PMID 1639266Read ↗

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