Article
A 10‐Mb paracentric inversion of chromosome arm 2p inactivates <i>MSH2</i> and is responsible for hereditary nonpolyposis colorectal cancer in a North‐American kindred
4 Apr 2002
Abstract excerpt
Genomic deletions of the MSH2 gene are a frequent cause of hereditary nonpolyposis colorectal cancer (HNPCC), a common hereditary predisposition to the development of tumors in several organs including the gastrointestinal and urinary tracts and endometrium. The mutation spectrum at the MSH2 gene is extremely heterogeneous because it includes nonsense and missense point mutations, small insertions and deletions...
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